The Structural Immunology book is edited by Prof. Jin and Prof. Yin is published in Nov, 2019 by Springer as part of the Advances in Experimental Medicine and Biology book series. It can be viewed at: https://link.springer.com/book/10.1007/978-981-13-9367-9.
This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.
Keywords
Structural immunology, Pattern recognition receptors, Structure and function of immune receptors, Molecular immunology, Innate immunity, Cytokines, Intracellular signaling complexes
Front Matter
Pages i-xiii PDF
Structural Basis for Signaling Through Shared Common γ Chain Cytokines
Huilin Yang, Rakeeb Kureshi, Jamie B. Spangler
Pages 1-19 PDF
Jiansheng Jiang, Kannan Natarajan, David H. Margulies
Pages 21-62 PDF
Structures of Immune Checkpoints: An Overview on the CD28-B7 Family
Weifeng Liu, Xingxing Zang
Pages 63-78 PDF
Interleukin-10 Family Cytokines Immunobiology and Structure
Huaxing Wei, Bofeng Li, Anyuan Sun, Feng Guo
Pages 79-96 PDF
Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors
Shenping Liu
Pages 97-117 PDF
Structural Biology of NOD-Like Receptors
Xinru Yang, Guangzhong Lin, Zhifu Han, Jijie Chai
Pages 119-141 PDF
AIM2 Inflammasome Assembly and Signaling
Bing Wang, Yuan Tian, Qian Yin
Pages 143-155 PDF
Structures of RIG-I-Like Receptors and Insights into Viral RNA Sensing
Xiaojiao Fan, Tengchuan Jin
Pages 157-188 PDF
Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death
Jianbin Ruan
Pages 189-205 PDF
NF-κB, IκB, and IKK: Integral Components of Immune System Signaling
Maria Carmen Mulero, Tom Huxford, Gourisankar Ghosh
Pages 207-226 PDF