范晓娇,2012年毕业于陕西师范大学,获得学士学位。2017年毕业于中国科学技术大学,获博士学位,研究方向为结构生物学。2020年与中国科学技术大学博士后出站。2020-2021年于西安交通大学担任助理研究员。2021-2025年于西安交通大学基础医学院担任副教授。2025年加入金腾川课题组,担任研究员。采用生物化学与分子生物学、细胞生物学、生物物理和结构生物学、生物信息学等 方法,研究癌症等疾病相关生物大分子的结构和功能,揭示其致病机制并进行药物研发。
Fan Xiaojiao, graduated from Shaanxi Normal University in 2012 with a bachelor's degree. She graduated from the University of Science and Technology of China in 2017 with a doctorate in structural biology. She completed her postdoctoral research at the University of Science and Technology of China in 2020. She worked as an assistant researcher at Xi'an Jiao tong University from 2020 to 2021. She worked as an associate professor at the School of Basic Medical Sciences of Xi'an Jiao tong University from 2021 to 2025. She joined TJ-lab in 2025 as a researcher. She uses biochemistry and molecular biology, cell biology, biophysics and structural biology, bioinformatics and other methods to study the structure and function of biomacromolecules related to diseases such as cancer, reveal their pathogenic mechanisms and conduct drug development.
Representative papers:
1. X. Fan, J. Jiang, D. Zhao, F. Chen, H. Ma, P. Smith, L. Unterholzner, T.S. Xiao, T. Jin, Structural mechanism of DNA recognition by the p204 HIN
domain, Nucleic Acids Res 49(5) (2021) 2959-2972.
2. X. Fan, L. Jiao, T. Jin, Activation and Immune Regulation Mechanisms of PYHIN Family During Microbial Infection, Front Microbiol 12 (2021)
809412.
3. H.M. Mengist, X. Fan, T. Jin, Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease M(pro), Signal
Transduct Target Ther 5(1) (2020) 67.
4. X. Fan, Y. Wang, F. Guo, Y. Zhang, T. Jin, Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different
substrate analogs, Int J Biol Macromol 164 (2020) 265-276.
5. X. Fan, T. Jin, Structures of RIG-I-Like Receptors and Insights into Viral RNA Sensing, Adv Exp Med Biol 1172 (2019) 157-188.