Decline of SARS-CoV-2 specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge
Dr. Huan Ma et al’s manuscript titled with ‘Decline of SARS-CoV-2 specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge’ was published online at Science China life science on 26th Aug, 2020. Congratulations.
The co-first authors of this paper are Huan Ma, Dan Zhao and Weihong Zeng. Prof. Tengchuan Jin and Prof. Xueying Zheng are corresponding authors. Congratulations to all authors.
Keywords: COVID-19, IgA, IgM, IgG, recovered patients
The levels of SARS-CoV-2 RBD-specific antibodies in most COVID-19 convalescent patients reduced significantly or remained low within the first 100 days after discharge. A mathematical modeling and extrapolation predicts that the virus-specific IgG in this group of convalescent patients will disappear in 273 days (~ 9 months), while the predicted decay times are 150 days and 108 days for IgM and IgA, respectively. Our data and analyses provide timely and critical information on how long acquired humoral immune responses to this new human coronavirus could persist.