马欢

马欢，特任副研究员，暨南大学博士。2016.7 -2020.7，中国科大博士后。2020.8至今，中国科大生命科学与医学部特任副研究员。主要从事抗体及蛋白质工程方面的研究。以第一及共同第一作者在Cell Res、Cell Dis、Cell Mol Immunol、JVI、Sci China Life Sci、Int J Biol Macromol等杂志发表论文。

代表性论文(#共同第一作者)：

1.         Huan Ma^#; Xinghai Zhang^#; Peiyi Zheng^#; Peter H. Dube^#; Weihong Zeng^#; Shaohong Chen^#; Qingyu Cheng; Yunru Yang; Yan Wu; Junhui Zhou; Xiaowen Hu; Yan Xiang*; Huajun Zhang*; Sandra Chiu*; Tengchuan Jin*. Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron. Cell Research, 2022 Sep;32(9):831-842.

2.         Huan Ma^#, Xinghai Zhang^#, Weihong Zeng^#, Junhui Zhou^#, Xiangyang Chi^#, Shaohong Chen, Peiyi Zheng, Meihua Wang, Yan Wu, Dan Zhao, Fanwu Gong, Haofeng Lin, Hancong Sun, Changming Yu, Zhengli Shi, Xiaowen Hu, Huajun Zhang*, Tengchuan Jin*, Sandra Chiu3*. A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration. Cell Discovery, 2022 Dec 9;8(1):132.

3.         Huan Ma^#; Weihong Zeng^#; Xiangzhi Meng; Xiaoxue Huang; Yunru Yang; Dan Zhao; Peigen Zhou; Xiangfang Wang; Changcheng Zhao; Yong Sun; Peihui Wang; Huichao Ou; Xiaowen Hu; Yan Xiang*; Tengchuan Jin*; Potent Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain. Journal of virology, 2021 Mar 3;95(10):e02438-20.

4.         Weihong Zeng^#; Huan Ma^#; Chengchao Ding^#; Yunru Yang; Yong Sun; Xiaoxue Huang; Weihuang He; Yan Xiang; Yong Gao*; Tengchuan Jin*; Characterization of SARS-CoV-2-specific antibodies in COVID-19 patients reveals highly potent neutralizing IgA. Signal Transduction and Targeted Therapy, 2021, 6(1):35.

5.         Huan Ma^#; Dan Zhao^#; Weihong Zeng^#; Yunru Yang; Xiaowen Hu; Peigen Zhou; Jianping Weng; Linzhao Cheng; Xueying Zheng*; Tengchuan Jin*; Decline of SARS-CoV-2-specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge. Science China Life Sciences, 2020, 28: 1-4.

6.         Huan Ma^#, Weihong Zeng^#, Hongliang He^#, Dan Zhao, Dehua Jiang, Peigen Zhou, Linzhao Cheng, Yajuan Li, Xiaoling Ma, Tengchuan Jin. Serum IgA, IgM, and IgG Responses in COVID-19. Cell Mol Immunol, 2020 Jul;17(7):773-775.

7.         Weihong Zeng^#, Huan Ma^#, Weirong Fan, Yunru Yang, Caiying Zhang, John Arnuad Kombe Kombe, Xiaojiao Fan, Yuzhu Zhang, Zhongjun Dong, Zhen Shen, Ying Zhou, Meixiang Yang, Tengchuan Jin. Structure determination of CAMP factor of Mobiluncus curtisii andinsight into structure dynamics, International Journal of Biological Macromolecules,2020, 150: 1027-1036.

联系方式：

工作邮箱：mahuan86@ustc.edu.cn