Ayesha's manuscript titled with Pharmacological inhibitors of NLRP3 inflammasome was published online at Frontiers in Immunology on Oct 25, 2019. Congratulations.
Currently, the first author of this paper, Miss Ayesha, is a 3rd year Ph.D student at USTC. Prof. Tengchuan Jin and Prof. Jinhui Tao of First affiliated hospital of USTC are corresponding authors. Congratulations to all authors.
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which is consist of NLRP3 (Nod-like receptor protein 3), ASC (apoptosis-related speck-like protein containing a caspase recruitment domain), and procaspase-1. Activation of NLRP3 inflammasome is mediated by highly diverse stimuli. Upon activation, NLRP3 protein recruits the adapter ASC protein, which recruits the procaspase-1 resulting in its cleavage and activation, ensuing the maturation and secretion of inflammatory cytokines and pyroptosis. However, aberrant activation of the NLRP3 inflammasome is implicated in various diseases including diabetes, atherosclerosis, metabolic syndrome, cardiovascular and neurodegenerative diseases; raising a tremendous clinical interest in exploring the potential inhibitors of NLRP3 inflammasome. Recent investigations have disclosed various inhibitors of the NLRP3 inflammasome pathway, which were validated through in vitro studies and in vivo experiments in animal models of NLRP3-associated disorders. Some of these inhibitors directly target the NLRP3 protein whereas some are aimed at other components and products of the inflammasome. Direct targeting of NLRP3 protein can be a better choice because it can prevent cytokine release and pyroptosis, thus restrain tissue destruction. This paper reviewed the various pharmacological inhibitors of the NLRP3 inflammasome and also discussed their mechanism of action.